Cyclooxygenase-2 (COX-2)–Independent Anticarcinogenic Effects of Selective COX-2 Inhibitors

Cyclooxygenase (COX-2) selective inhibitors. Any better than NSAIDs?

Anti-inflammatory effects of selective COX-2 inhibitors.

In this study, effects of rofecoxib, celecoxib, nimesulide on the acute phase of inflammation were studied in the carrageenan-induced paw edema model and their influence on the chronic phase of inflammation was evaluated in the cotton pellet granuloma tests. Additionally, effects of these drugs on capillary vascular permeability were examined in the hyaluronidase test and were compared with tha...

Gastrointestinal tolerability of the selective cyclooxygenase-2 (COX-2) inhibitor rofecoxib compared with nonselective COX-1 and COX-2 inhibitors in osteoarthritis.

BACKGROUND Most nonsteroidal anti-inflammatory drugs (NSAIDs) are nonselective cyclooxygenase (COX-1 and COX-2) inhibitors and are associated with a variety of upper gastrointestinal (GI) tract symptoms. The roles of COX-1 and COX-2 in the pathogenesis of these symptoms are unclear. To test whether COX-2 inhibition with rofecoxib would have greater GI tolerability than nonselective COX-1 and CO...

A Discussion on Chemoprevention of Oral Cancer by Selective Cyclooxygenase-2 (cox-2) Inhibitors

A. K. SINGH, A. PANDEY, M. TEWARI, KUMAR PRAKASH, H. S. SHUKLA, H. P. PANDEY Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi, India Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India Department of Biotechnology, IBMER, Mangalayatan University, Aligarh, India Department of Statistics, Faculty of Science, Ba...

design and synthesis of new isoquinoline derivatives as selective cyclooxygenase-2 (cox-2) inhibitors and their molecular modeling studies